ALNY Alnylam Pharmaceuticals Inc
Health Care > Pharmaceuticals, Biotechnology & Life Sciences > Biotechnology > Biotechnology | NASDAQ, LargeCap, ObesityDrugs | Last Price: 333 | 2026-04-13 | Atrp: 3.57
Tue 07 Apr 2026 to Mon 13 Apr 2026: Score -3
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | PEG Ratio | 0.6397 | 0.6462 | ▲ 1.02% | Bearish. Lower is better. Slight increase, worsening the value relative to growth P/E ratio adjusted for growth rate |
| â | Forward PE | 36.1011 | 36.4964 | ▲ 1.09% | Bearish. Lower is better. Slight decline Stock price divided by expected future earnings |
| â | Price Book MRQ | 53.5836 | 54.4599 | ▲ 1.64% | Bearish. Lower is better. Further to 1; more overvalued on assets but worsened perception Stock price divided by book value per share for the most recent quarter |
| â | Enterprise Value/Revenue | 10.9471 | 11.1333 | ▲ 1.7% | Bearish. Lower is better. Slight decline Enterprise value divided by revenue |
| â | Enterprise Value/EBITDA | 64.3877 | 65.483 | ▲ 1.7% | Bearish. Lower is better. Slight decline Enterprise value to earnings before interest, taxes, depreciation |
| â | Price Sales TTM | 11.7963 | 11.5024 | ▼ -2.49% | Bullish. Lower is better. Lower multiple; market willing to pay less per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
| â | Enterprise Value | $40.66B | $41.35B | ▲ 1.7% | Bullish. Higher is better. Increased, reflecting higher market cap and possibly debt adjustments Market capitalization plus debt minus cash |
Tue 31 Mar 2026 to Tue 07 Apr 2026: Score -6
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Forward PE | 32.8947 | 36.1011 | ▲ 9.75% | Bearish. Lower is better. Slight decline Stock price divided by expected future earnings |
| â | Price Sales TTM | 11.2874 | 11.7963 | ▲ 4.51% | Bearish. Lower is better. Higher multiple; market willing to pay more per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
| â | Price Book MRQ | 52.461 | 53.5836 | ▲ 2.14% | Bearish. Lower is better. Further to 1; more overvalued on assets but worsened perception Stock price divided by book value per share for the most recent quarter |
| â | Enterprise Value/Revenue | 10.7085 | 10.9471 | ▲ 2.23% | Bearish. Lower is better. Slight decline Enterprise value divided by revenue |
| â | Enterprise Value/EBITDA | 62.9847 | 64.3877 | ▲ 2.23% | Bearish. Lower is better. Slight decline Enterprise value to earnings before interest, taxes, depreciation |
| â | Enterprise Value | $39.77B | $40.66B | ▲ 2.23% | Bullish. Higher is better. Increased, reflecting higher market cap and possibly debt adjustments Market capitalization plus debt minus cash |
Tue 17 Mar 2026 to Tue 31 Mar 2026: Score -10
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | PEG Ratio | -0.49 | 0.6367 | ▲ 229.94% | Bearish. Lower is better. Extreme increase, worsening the value relative to growth P/E ratio adjusted for growth rate |
| â | Short Ratio | 3.05 | 4.2 | ▲ 37.7% | Bearish. Lower is better. Significant decline |
| â | Wall Street Target Price | 457 | 449.32 | ▼ -1.68% | Bearish. Higher is better. Lower analyst expectations, pointing to decreased optimism for future performance Analysts' consensus target price for the stock |
| â | EPS Estimate Current Year | 9.5585 | 9.2535 | ▼ -3.19% | Bearish. Higher is better. Slight decrease; reduced outlook for current year earnings Expected earnings per share this year |
| â | EPS Estimate Next Year | 14.5392 | 14.2027 | ▼ -2.31% | Bearish. Higher is better. Slight lowered expectations for further out Expected earnings per share next year |
| â | Forward PE | 34.1297 | 32.8947 | ▼ -3.62% | Bullish. Lower is better. Slight improvement Stock price divided by expected future earnings |
| â | Short Percent | 4.53% | 4.33% | ▼ -4.42% | Bullish. Lower is better. Slight decrease; still high, potential for squeeze if positive catalysts emerge Percentage of shares sold short |
Sun 08 Mar 2026 to Tue 17 Mar 2026: Score 8
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Short Percent | 5.19% | 4.53% | ▼ -12.72% | Bullish. Lower is better. Moderate decrease; still high, potential for squeeze if positive catalysts emerge Percentage of shares sold short |
| â | Short Ratio | 3.21 | 3.05 | ▼ -4.98% | Bullish. Lower is better. Slight improvement |
| â | Forward PE | 34.965 | 34.1297 | ▼ -2.39% | Bullish. Lower is better. Slight improvement Stock price divided by expected future earnings |
| â | Price Book MRQ | 53.8878 | 52.6694 | ▼ -2.26% | Bullish. Lower is better. Closer to 1; less overvalued on assets but improved perception Stock price divided by book value per share for the most recent quarter |
| â | Enterprise Value/Revenue | 11.0117 | 10.7528 | ▼ -2.35% | Bullish. Lower is better. Slight improvement Enterprise value divided by revenue |
| â | Enterprise Value/EBITDA | 64.7679 | 63.2451 | ▼ -2.35% | Bullish. Lower is better. Slight improvement Enterprise value to earnings before interest, taxes, depreciation |
| â | Enterprise Value | $40.9B | $39.94B | ▼ -2.35% | Bearish. Higher is better. Decreased, reflecting lower market cap and possibly debt adjustments Market capitalization plus debt minus cash |
Fri 27 Feb 2026 to Sun 08 Mar 2026: Score 14
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Price Book MRQ | 241.1344 | 53.8878 | ▼ -77.65% | Bullish. Lower is better. Closer to 1; less overvalued on assets but improved perception Stock price divided by book value per share for the most recent quarter |
| â | Enterprise Value/EBITDA | 204.8549 | 64.7679 | ▼ -68.38% | Bullish. Lower is better. Substantial improvement Enterprise value to earnings before interest, taxes, depreciation |
| â | Enterprise Value/Revenue | 23.91 | 11.0117 | ▼ -53.95% | Bullish. Lower is better. Substantial improvement Enterprise value divided by revenue |
| â | Forward PE | 46.5116 | 34.965 | ▼ -24.83% | Bullish. Lower is better. Significant improvement Stock price divided by expected future earnings |
| â | Price Sales TTM | 11.8284 | 11.4506 | ▼ -3.19% | Bullish. Lower is better. Lower multiple; market willing to pay less per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
| â | Enterprise Value | $58.87B | $40.9B | ▼ -30.53% | Bearish. Higher is better. Decreased, reflecting lower market cap and possibly debt adjustments Market capitalization plus debt minus cash |
Fri 20 Feb 2026 to Fri 27 Feb 2026: Score -11
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Price Book MRQ | 52.8358 | 241.1344 | ▲ 356.38% | Bearish. Lower is better. Further to 1; more overvalued on assets but worsened perception Stock price divided by book value per share for the most recent quarter |
| â | Enterprise Value/EBITDA | 63.4531 | 204.8549 | ▲ 222.84% | Bearish. Lower is better. Extreme decline Enterprise value to earnings before interest, taxes, depreciation |
| â | Enterprise Value/Revenue | 10.7882 | 23.91 | ▲ 121.63% | Bearish. Lower is better. Extreme decline Enterprise value divided by revenue |
| â | Forward PE | 41.841 | 46.5116 | ▲ 11.16% | Bearish. Lower is better. Moderate decline Stock price divided by expected future earnings |
| â | Price Sales TTM | 12.1188 | 11.8284 | ▼ -2.4% | Bullish. Lower is better. Lower multiple; market willing to pay less per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
| â | Short Percent | 5.26% | 5.19% | ▼ -1.33% | Bullish. Lower is better. Slight decrease; still high, potential for squeeze if positive catalysts emerge Percentage of shares sold short |
| â | Short Ratio | 3.72 | 3.21 | ▼ -13.71% | Bullish. Lower is better. Moderate improvement |
| â | Enterprise Value | $40.07B | $58.87B | ▲ 46.92% | Bullish. Higher is better. Increased, reflecting higher market cap and possibly debt adjustments Market capitalization plus debt minus cash |
Fri 13 Feb 2026 to Fri 20 Feb 2026: Score 23
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Profit Margin | 1.36% | 8.45% | ▲ 521.32% | Bullish. Higher is better. Profit margin growth accelerating. Percentage of revenue that turns into profit |
| â | Book Value | 1.775 | 5.962 | ▲ 235.89% | Bullish. Higher is better. Extreme increase; stock now trades closer to book value Net asset value of the company per share |
| â | EBITDA | $321.02M | $557.24M | ▲ 73.58% | Bullish. Higher is better. Increase in earnings before interest, taxes, depreciation, and amortization; indicates stronger operational cash flow Earnings before interest, taxes, depreciation, and amortization |
| â | Return On Equity TTM | 32.72% | 73.28% | ▲ 123.96% | Bullish. Higher is better. Return on equity TTM growth accelerating. Efficiency in generating profits from shareholders' equity |
| â | Return On Assets TTM | 3.65% | 6.81% | ▲ 86.58% | Bullish. Higher is better. Return on assets TTM growth accelerating. Efficiency in generating profits from total assets |
| â | Gross Profit TTM | $2693.1M | $3032.07M | ▲ 12.59% | Bullish. Higher is better. Moderate increase, but margins may be improving Revenue minus cost of goods sold over the trailing twelve months |
| â | Revenue TTM | $3210.07M | $3713.94M | ▲ 15.7% | Bullish. Higher is better. Moderate top-line expansion Total revenue over the trailing twelve months |
| â | Revenue Per Share TTM | 24.65 | 28.35 | ▲ 15.01% | Bullish. Higher is better. Moderate improvement Revenue generated per outstanding share over the trailing twelve months |
| â | Price Sales TTM | 12.6958 | 12.1188 | ▼ -4.54% | Bullish. Lower is better. Lower multiple; market willing to pay less per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
| â | Forward PE | 42.3729 | 41.841 | ▼ -1.26% | Bullish. Lower is better. Slight improvement Stock price divided by expected future earnings |
| â | Enterprise Value | $39.12B | $40.07B | ▲ 2.41% | Bullish. Higher is better. Increased, reflecting higher market cap and possibly debt adjustments Market capitalization plus debt minus cash |
| â | Price Book MRQ | 51.6418 | 52.8358 | ▲ 2.31% | Bearish. Lower is better. Further to 1; more overvalued on assets but worsened perception Stock price divided by book value per share for the most recent quarter |
| â | Enterprise Value/Revenue | 10.5345 | 10.7882 | ▲ 2.41% | Bearish. Lower is better. Slight decline Enterprise value divided by revenue |
| â | Enterprise Value/EBITDA | 61.9609 | 63.4531 | ▲ 2.41% | Bearish. Lower is better. Slight decline Enterprise value to earnings before interest, taxes, depreciation |
| â | Institutional Ownership | 104.068% | 101.74% | ▼ -2.24% | Bearish. Higher is better. Slight decline; reduced interest from big investors Percentage held by institutions like mutual funds |
| â | Wall Street Target Price | 477.5829 | 457 | ▼ -4.31% | Bearish. Higher is better. Lower analyst expectations, pointing to decreased optimism for future performance Analysts' consensus target price for the stock |
| â | EPS Estimate Current Year | 10.2761 | 9.5585 | ▼ -6.98% | Bearish. Higher is better. Slight decrease; reduced outlook for current year earnings Expected earnings per share this year |
| â | EPS Estimate Next Year | 16.079 | 14.5392 | ▼ -9.58% | Bearish. Higher is better. Slight lowered expectations for further out Expected earnings per share next year |
| â | Operating Margin TTM | 29.46% | 12.01% | ▼ -59.23% | Bearish. Higher is better. Operating margin TTM growth slowing. Percentage of revenue left after operating expenses |
| â | Quarterly Revenue Growth YOY | 1491% | 851% | ▼ -43.13% | Bearish. Higher is better. Quarterly revenue growth YOY growth slowing. Year-over-year growth in quarterly revenue |
Fri 06 Feb 2026 to Fri 13 Feb 2026: Score 30
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Earnings Per Share | 0.3 | 2.34 | ▲ 680% | Bullish. Higher is better. Extreme increase in earnings per share Profit allocated to each outstanding share |
| â | EPS Estimate Current Year | 4.7911 | 10.2761 | ▲ 114.48% | Bullish. Higher is better. Extreme increase; improved outlook for current year earnings Expected earnings per share this year |
| â | Price Book MRQ | 187.0992 | 51.6418 | ▼ -72.4% | Bullish. Lower is better. Closer to 1; less overvalued on assets but improved perception Stock price divided by book value per share for the most recent quarter |
| â | Enterprise Value/EBITDA | 226.8842 | 61.9609 | ▼ -72.69% | Bullish. Lower is better. Substantial improvement Enterprise value to earnings before interest, taxes, depreciation |
| â | EPS Estimate Next Year | 10.5876 | 16.079 | ▲ 51.87% | Bullish. Higher is better. Substantial raised expectations for further out Expected earnings per share next year |
| â | Enterprise Value/Revenue | 13.1914 | 10.5345 | ▼ -20.14% | Bullish. Lower is better. Significant improvement Enterprise value divided by revenue |
| â | Forward PE | 45.4545 | 42.3729 | ▼ -6.78% | Bullish. Lower is better. Slight improvement Stock price divided by expected future earnings |
| â | Price Sales TTM | 13.6325 | 12.6958 | ▼ -6.87% | Bullish. Lower is better. Lower multiple; market willing to pay less per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
| â | Short Percent | 5.54% | 5.26% | ▼ -5.05% | Bullish. Lower is better. Slight decrease; still high, potential for squeeze if positive catalysts emerge Percentage of shares sold short |
| â | Enterprise Value | $42.35B | $39.12B | ▼ -7.61% | Bearish. Higher is better. Decreased, reflecting lower market cap and possibly debt adjustments Market capitalization plus debt minus cash |
| â | Short Ratio | 3.22 | 3.72 | ▲ 15.53% | Bearish. Lower is better. Moderate decline |
Fri 30 Jan 2026 to Fri 06 Feb 2026: Score 4
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Forward PE | 47.619 | 45.4545 | ▼ -4.55% | Bullish. Lower is better. Slight improvement Stock price divided by expected future earnings |
| â | Price Book MRQ | 195.8825 | 187.0992 | ▼ -4.48% | Bullish. Lower is better. Closer to 1; less overvalued on assets but improved perception Stock price divided by book value per share for the most recent quarter |
| â | Enterprise Value/Revenue | 13.8313 | 13.1914 | ▼ -4.63% | Bullish. Lower is better. Slight improvement Enterprise value divided by revenue |
| â | Enterprise Value/EBITDA | 237.8914 | 226.8842 | ▼ -4.63% | Bullish. Lower is better. Slight improvement Enterprise value to earnings before interest, taxes, depreciation |
| â | Price Sales TTM | 13.9807 | 13.6325 | ▼ -2.49% | Bullish. Lower is better. Lower multiple; market willing to pay less per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
| â | Earnings Per Share | 0.31 | 0.3 | ▼ -3.23% | Bearish. Higher is better. Slight decline in earnings per share Profit allocated to each outstanding share |
| â | EPS Estimate Next Year | 11.1437 | 10.5876 | ▼ -4.99% | Bearish. Higher is better. Slight lowered expectations for further out Expected earnings per share next year |
| â | Enterprise Value | $44.4B | $42.35B | ▼ -4.63% | Bearish. Higher is better. Decreased, reflecting lower market cap and possibly debt adjustments Market capitalization plus debt minus cash |
Fri 23 Jan 2026 to Fri 30 Jan 2026: Score 11
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Forward PE | 50.7614 | 47.619 | ▼ -6.19% | Bullish. Lower is better. Slight improvement Stock price divided by expected future earnings |
| â | Price Sales TTM | 15.2277 | 13.9807 | ▼ -8.19% | Bullish. Lower is better. Lower multiple; market willing to pay less per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
| â | Price Book MRQ | 208.9926 | 195.8825 | ▼ -6.27% | Bullish. Lower is better. Closer to 1; less overvalued on assets but improved perception Stock price divided by book value per share for the most recent quarter |
| â | Enterprise Value/Revenue | 14.7866 | 13.8313 | ▼ -6.46% | Bullish. Lower is better. Slight improvement Enterprise value divided by revenue |
| â | Enterprise Value/EBITDA | 254.3209 | 237.8914 | ▼ -6.46% | Bullish. Lower is better. Slight improvement Enterprise value to earnings before interest, taxes, depreciation |
| â | Short Ratio | 3.39 | 3.22 | ▼ -5.01% | Bullish. Lower is better. Slight improvement |
| â | Earnings Per Share | 0.3 | 0.31 | ▲ 3.33% | Bullish. Higher is better. Slight increase in earnings per share Profit allocated to each outstanding share |
| â | Enterprise Value | $46.87B | $44.4B | ▼ -5.26% | Bearish. Higher is better. Decreased, reflecting lower market cap and possibly debt adjustments Market capitalization plus debt minus cash |
Wed 14 Jan 2026 to Fri 23 Jan 2026: Score -1
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Wall Street Target Price | 493.2796 | 485.7596 | ▼ -1.52% | Bearish. Higher is better. Lower analyst expectations, pointing to decreased optimism for future performance Analysts' consensus target price for the stock |
| â | Enterprise Value | $47.59B | $46.87B | ▼ -1.51% | Bearish. Higher is better. Decreased, reflecting lower market cap and possibly debt adjustments Market capitalization plus debt minus cash |
| â | Forward PE | 52.0833 | 50.7614 | ▼ -2.54% | Bullish. Lower is better. Slight improvement Stock price divided by expected future earnings |
Tue 06 Jan 2026 to Wed 14 Jan 2026: Score -1
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Short Percent | 4.16% | 5.51% | ▲ 32.45% | Bearish. Lower is better. Significant increase; still high, potential for squeeze if positive catalysts emerge Percentage of shares sold short |
| â | Forward PE | 45.2489 | 52.0833 | ▲ 15.1% | Bearish. Lower is better. Moderate decline Stock price divided by expected future earnings |
| â | Earnings Per Share | 0.32 | 0.3 | ▼ -6.25% | Bearish. Higher is better. Slight decline in earnings per share Profit allocated to each outstanding share |
| â | Enterprise Value | $51.45B | $47.59B | ▼ -7.51% | Bearish. Higher is better. Decreased, reflecting lower market cap and possibly debt adjustments Market capitalization plus debt minus cash |
| â | EPS Estimate Current Year | 4.9558 | 4.8004 | ▼ -3.14% | Bearish. Higher is better. Slight decrease; reduced outlook for current year earnings Expected earnings per share this year |
| â | Institutional Ownership | 100.243% | 102.855% | ▲ 2.61% | Bullish. Higher is better. Slight increase; continued strong interest from big investors Percentage held by institutions like mutual funds |
| â | Price Sales TTM | 16.3731 | 15.2261 | ▼ -7.01% | Bullish. Lower is better. Lower multiple; market willing to pay less per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
| â | Price Book MRQ | 226.034 | 209.5066 | ▼ -7.31% | Bullish. Lower is better. Closer to 1; less overvalued on assets but improved perception Stock price divided by book value per share for the most recent quarter |
| â | Enterprise Value/Revenue | 16.0283 | 14.824 | ▼ -7.51% | Bullish. Lower is better. Slight improvement Enterprise value divided by revenue |
| â | Enterprise Value/EBITDA | 275.6771 | 254.965 | ▼ -7.51% | Bullish. Lower is better. Slight improvement Enterprise value to earnings before interest, taxes, depreciation |
| â | Short Ratio | 3.57 | 3.39 | ▼ -5.04% | Bullish. Lower is better. Slight improvement |
Sun 21 Dec 2025 to Tue 06 Jan 2026: Score 4
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Earnings Per Share | 0.28 | 0.32 | ▲ 14.29% | Bullish. Higher is better. Moderate increase in earnings per share Profit allocated to each outstanding share |
| â | EPS Estimate Next Year | 10.6099 | 11.1822 | ▲ 5.39% | Bullish. Higher is better. Slight raised expectations for further out Expected earnings per share next year |
| â | Short Ratio | 3.67 | 3.57 | ▼ -2.72% | Bullish. Lower is better. Slight improvement |
| â | Short Percent | 3.94% | 4.16% | ▲ 5.58% | Bearish. Lower is better. Slight increase; still high, potential for squeeze if positive catalysts emerge Percentage of shares sold short |