ALNY Alnylam Pharmaceuticals Inc
Health Care > Pharmaceuticals, Biotechnology & Life Sciences > Biotechnology > Biotechnology | NASDAQ, LargeCap, ObesityDrugs | Last Price: 332.92 | 2026-02-27 | Atrp: 3.79
Sat 21 Feb 2026 to Fri 27 Feb 2026: Score -8
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Price Book MRQ | 57.032 | 241.1344 | ▲ 322.81% | Bearish. Lower is better. Further to 1; more overvalued on assets but worsened perception Stock price divided by book value per share for the most recent quarter |
| â | Enterprise Value/EBITDA | 68.6976 | 204.8549 | ▲ 198.2% | Bearish. Lower is better. Extreme decline Enterprise value to earnings before interest, taxes, depreciation |
| â | Enterprise Value/Revenue | 11.6798 | 23.91 | ▲ 104.71% | Bearish. Lower is better. Extreme decline Enterprise value divided by revenue |
| â | Price Sales TTM | 12.0052 | 11.8284 | ▼ -1.47% | Bullish. Lower is better. Lower multiple; market willing to pay less per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
| â | Short Percent | 5.26% | 5.19% | ▼ -1.33% | Bullish. Lower is better. Slight decrease; still high, potential for squeeze if positive catalysts emerge Percentage of shares sold short |
| â | Short Ratio | 3.72 | 3.21 | ▼ -13.71% | Bullish. Lower is better. Moderate improvement |
| â | Enterprise Value | $43.38B | $58.87B | ▲ 35.7% | Bullish. Higher is better. Increased, reflecting higher market cap and possibly debt adjustments Market capitalization plus debt minus cash |
Sat 14 Feb 2026 to Sat 21 Feb 2026: Score -15
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Price Book MRQ | 51.6418 | 57.032 | ▲ 10.44% | Bearish. Lower is better. Further to 1; more overvalued on assets but worsened perception Stock price divided by book value per share for the most recent quarter |
| â | Enterprise Value/Revenue | 10.5345 | 11.6798 | ▲ 10.87% | Bearish. Lower is better. Moderate decline Enterprise value divided by revenue |
| â | Enterprise Value/EBITDA | 61.9609 | 68.6976 | ▲ 10.87% | Bearish. Lower is better. Moderate decline Enterprise value to earnings before interest, taxes, depreciation |
| â | EPS Estimate Next Year | 15.3565 | 14.5392 | ▼ -5.32% | Bearish. Higher is better. Slight lowered expectations for further out Expected earnings per share next year |
| â | Forward PE | 42.3729 | 46.5116 | ▲ 9.77% | Bearish. Lower is better. Slight decline Stock price divided by expected future earnings |
| â | Price Sales TTM | 11.2271 | 12.0052 | ▲ 6.93% | Bearish. Lower is better. Higher multiple; market willing to pay more per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
| â | Wall Street Target Price | 467.6246 | 457 | ▼ -2.27% | Bearish. Higher is better. Lower analyst expectations, pointing to decreased optimism for future performance Analysts' consensus target price for the stock |
| â | EPS Estimate Current Year | 9.8308 | 9.5585 | ▼ -2.77% | Bearish. Higher is better. Slight decrease; reduced outlook for current year earnings Expected earnings per share this year |
| â | Institutional Ownership | 103.696% | 101.81% | ▼ -1.82% | Bearish. Higher is better. Slight decline; reduced interest from big investors Percentage held by institutions like mutual funds |
| â | Enterprise Value | $39.12B | $43.38B | ▲ 10.87% | Bullish. Higher is better. Increased, reflecting higher market cap and possibly debt adjustments Market capitalization plus debt minus cash |
Sat 07 Feb 2026 to Sat 14 Feb 2026: Score 59
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Earnings Per Share | 0.3 | 2.33 | ▲ 676.67% | Bullish. Higher is better. Extreme increase in earnings per share Profit allocated to each outstanding share |
| â | Profit Margin | 1.36% | 8.45% | ▲ 521.32% | Bullish. Higher is better. Profit margin growth accelerating. Percentage of revenue that turns into profit |
| â | Book Value | 1.775 | 5.962 | ▲ 235.89% | Bullish. Higher is better. Extreme increase; stock now trades closer to book value Net asset value of the company per share |
| â | EBITDA | $321.02M | $557.24M | ▲ 73.58% | Bullish. Higher is better. Increase in earnings before interest, taxes, depreciation, and amortization; indicates stronger operational cash flow Earnings before interest, taxes, depreciation, and amortization |
| â | EPS Estimate Current Year | 4.7911 | 9.8308 | ▲ 105.19% | Bullish. Higher is better. Extreme increase; improved outlook for current year earnings Expected earnings per share this year |
| â | Return On Equity TTM | 32.72% | 73.28% | ▲ 123.96% | Bullish. Higher is better. Return on equity TTM growth accelerating. Efficiency in generating profits from shareholders' equity |
| â | Return On Assets TTM | 3.65% | 6.81% | ▲ 86.58% | Bullish. Higher is better. Return on assets TTM growth accelerating. Efficiency in generating profits from total assets |
| â | Price Book MRQ | 187.0992 | 51.6418 | ▼ -72.4% | Bullish. Lower is better. Closer to 1; less overvalued on assets but improved perception Stock price divided by book value per share for the most recent quarter |
| â | Enterprise Value/EBITDA | 226.8842 | 61.9609 | ▼ -72.69% | Bullish. Lower is better. Substantial improvement Enterprise value to earnings before interest, taxes, depreciation |
| â | EPS Estimate Next Year | 10.5876 | 15.3565 | ▲ 45.04% | Bullish. Higher is better. Significant raised expectations for further out Expected earnings per share next year |
| â | Gross Profit TTM | $2693.1M | $3036.77M | ▲ 12.76% | Bullish. Higher is better. Moderate increase, but margins may be improving Revenue minus cost of goods sold over the trailing twelve months |
| â | Revenue TTM | $3210.07M | $3713.94M | ▲ 15.7% | Bullish. Higher is better. Moderate top-line expansion Total revenue over the trailing twelve months |
| â | Revenue Per Share TTM | 24.65 | 28.35 | ▲ 15.01% | Bullish. Higher is better. Moderate improvement Revenue generated per outstanding share over the trailing twelve months |
| â | Price Sales TTM | 13.5058 | 11.2271 | ▼ -16.87% | Bullish. Lower is better. Lower multiple; market willing to pay less per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
| â | Enterprise Value/Revenue | 13.1914 | 10.5345 | ▼ -20.14% | Bullish. Lower is better. Significant improvement Enterprise value divided by revenue |
| â | Forward PE | 45.4545 | 42.3729 | ▼ -6.78% | Bullish. Lower is better. Slight improvement Stock price divided by expected future earnings |
| â | Short Percent | 5.54% | 5.26% | ▼ -5.05% | Bullish. Lower is better. Slight decrease; still high, potential for squeeze if positive catalysts emerge Percentage of shares sold short |
| â | Wall Street Target Price | 479.7913 | 467.6246 | ▼ -2.54% | Bearish. Higher is better. Lower analyst expectations, pointing to decreased optimism for future performance Analysts' consensus target price for the stock |
| â | Enterprise Value | $42.35B | $39.12B | ▼ -7.61% | Bearish. Higher is better. Decreased, reflecting lower market cap and possibly debt adjustments Market capitalization plus debt minus cash |
| â | Short Ratio | 3.22 | 3.72 | ▲ 15.53% | Bearish. Lower is better. Moderate decline |
| â | Operating Margin TTM | 29.46% | 12.01% | ▼ -59.23% | Bearish. Higher is better. Operating margin TTM growth slowing. Percentage of revenue left after operating expenses |
| â | Quarterly Revenue Growth YOY | 1491% | 851% | ▼ -43.13% | Bearish. Higher is better. Quarterly revenue growth YOY growth slowing. Year-over-year growth in quarterly revenue |
Sat 31 Jan 2026 to Sat 07 Feb 2026: Score 7
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Forward PE | 47.619 | 45.4545 | ▼ -4.55% | Bullish. Lower is better. Slight improvement Stock price divided by expected future earnings |
| â | Price Book MRQ | 195.8825 | 187.0992 | ▼ -4.48% | Bullish. Lower is better. Closer to 1; less overvalued on assets but improved perception Stock price divided by book value per share for the most recent quarter |
| â | Enterprise Value/Revenue | 13.8313 | 13.1914 | ▼ -4.63% | Bullish. Lower is better. Slight improvement Enterprise value divided by revenue |
| â | Enterprise Value/EBITDA | 237.8914 | 226.8842 | ▼ -4.63% | Bullish. Lower is better. Slight improvement Enterprise value to earnings before interest, taxes, depreciation |
| â | Price Sales TTM | 13.9132 | 13.5058 | ▼ -2.93% | Bullish. Lower is better. Lower multiple; market willing to pay less per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
| â | Enterprise Value | $44.4B | $42.35B | ▼ -4.63% | Bearish. Higher is better. Decreased, reflecting lower market cap and possibly debt adjustments Market capitalization plus debt minus cash |
Sat 24 Jan 2026 to Sat 31 Jan 2026: Score 5
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Price Sales TTM | 14.733 | 13.9132 | ▼ -5.56% | Bullish. Lower is better. Lower multiple; market willing to pay less per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
| â | Short Ratio | 3.39 | 3.22 | ▼ -5.01% | Bullish. Lower is better. Slight improvement |
| â | Earnings Per Share | 0.29 | 0.3 | ▲ 3.45% | Bullish. Higher is better. Slight increase in earnings per share Profit allocated to each outstanding share |
| â | Forward PE | 49.0196 | 47.619 | ▼ -2.86% | Bullish. Lower is better. Slight improvement Stock price divided by expected future earnings |
| â | Price Book MRQ | 202.2032 | 195.8825 | ▼ -3.13% | Bullish. Lower is better. Closer to 1; less overvalued on assets but improved perception Stock price divided by book value per share for the most recent quarter |
| â | Enterprise Value/Revenue | 14.2919 | 13.8313 | ▼ -3.22% | Bullish. Lower is better. Slight improvement Enterprise value divided by revenue |
| â | Enterprise Value/EBITDA | 245.8124 | 237.8914 | ▼ -3.22% | Bullish. Lower is better. Slight improvement Enterprise value to earnings before interest, taxes, depreciation |
| â | Wall Street Target Price | 485.7596 | 477.1996 | ▼ -1.76% | Bearish. Higher is better. Lower analyst expectations, pointing to decreased optimism for future performance Analysts' consensus target price for the stock |
| â | Enterprise Value | $45.88B | $44.4B | ▼ -3.22% | Bearish. Higher is better. Decreased, reflecting lower market cap and possibly debt adjustments Market capitalization plus debt minus cash |
| â | EPS Estimate Next Year | 11.2353 | 10.5682 | ▼ -5.94% | Bearish. Higher is better. Slight lowered expectations for further out Expected earnings per share next year |
Sat 10 Jan 2026 to Sat 17 Jan 2026: Score 9
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Forward PE | 56.1798 | 50.5051 | ▼ -10.1% | Bullish. Lower is better. Moderate improvement Stock price divided by expected future earnings |
| â | Price Book MRQ | 225.599 | 202.9318 | ▼ -10.05% | Bullish. Lower is better. Closer to 1; less overvalued on assets but improved perception Stock price divided by book value per share for the most recent quarter |
| â | Enterprise Value/Revenue | 15.9966 | 14.345 | ▼ -10.32% | Bullish. Lower is better. Moderate improvement Enterprise value divided by revenue |
| â | Enterprise Value/EBITDA | 275.132 | 246.7255 | ▼ -10.32% | Bullish. Lower is better. Moderate improvement Enterprise value to earnings before interest, taxes, depreciation |
| â | EPS Estimate Next Year | 10.7399 | 11.2353 | ▲ 4.61% | Bullish. Higher is better. Slight raised expectations for further out Expected earnings per share next year |
| â | Price Sales TTM | 16.392 | 14.7861 | ▼ -9.8% | Bullish. Lower is better. Lower multiple; market willing to pay less per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
| â | Short Ratio | 3.57 | 3.39 | ▼ -5.04% | Bullish. Lower is better. Slight improvement |
| â | Earnings Per Share | 0.32 | 0.29 | ▼ -9.38% | Bearish. Higher is better. Slight decline in earnings per share Profit allocated to each outstanding share |
| â | Enterprise Value | $51.35B | $46.05B | ▼ -10.32% | Bearish. Higher is better. Decreased, reflecting lower market cap and possibly debt adjustments Market capitalization plus debt minus cash |
| â | Short Percent | 4.16% | 5.51% | ▲ 32.45% | Bearish. Lower is better. Significant increase; still high, potential for squeeze if positive catalysts emerge Percentage of shares sold short |
Sat 03 Jan 2026 to Sat 10 Jan 2026: Score -2
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Forward PE | 44.843 | 56.1798 | ▲ 25.28% | Bearish. Lower is better. Significant decline Stock price divided by expected future earnings |
| â | EPS Estimate Current Year | 4.9558 | 4.8242 | ▼ -2.66% | Bearish. Higher is better. Slight decrease; reduced outlook for current year earnings Expected earnings per share this year |
| â | EPS Estimate Next Year | 11.1822 | 10.7399 | ▼ -3.96% | Bearish. Higher is better. Slight lowered expectations for further out Expected earnings per share next year |
| â | Institutional Ownership | 100.249% | 102.736% | ▲ 2.48% | Bullish. Higher is better. Slight increase; continued strong interest from big investors Percentage held by institutions like mutual funds |
| â | Earnings Per Share | 0.28 | 0.32 | ▲ 14.29% | Bullish. Higher is better. Moderate increase in earnings per share Profit allocated to each outstanding share |
Sun 21 Dec 2025 to Sat 03 Jan 2026: Score 1
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | EPS Estimate Next Year | 10.6099 | 11.1822 | ▲ 5.39% | Bullish. Higher is better. Slight raised expectations for further out Expected earnings per share next year |
| â | Short Ratio | 3.67 | 3.57 | ▼ -2.72% | Bullish. Lower is better. Slight improvement |
| â | Short Percent | 3.94% | 4.16% | ▲ 5.58% | Bearish. Lower is better. Slight increase; still high, potential for squeeze if positive catalysts emerge Percentage of shares sold short |