VRTX Vertex Pharmaceuticals Inc
Health Care > Pharmaceuticals, Biotechnology & Life Sciences > Biotechnology > Biotechnology | NASDAQ, LargeCap, BiotechHealthcare | Last Price: 441.2 | 2026-04-17 | Atrp: 2.67
Sun 12 Apr 2026 to Sat 18 Apr 2026: Score 1
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Short Ratio | 2.9 | 2.8 | ▼ -3.45% | Bullish. Lower is better. Slight improvement |
| â | Short Percent | 1.83% | 1.78% | ▼ -2.73% | Bullish. Lower is better. Slight decrease; still high, potential for squeeze if positive catalysts emerge Percentage of shares sold short |
| â | Price Sales TTM | 9.2465 | 9.3509 | ▲ 1.13% | Bearish. Lower is better. Higher multiple; market willing to pay more per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
Sun 29 Mar 2026 to Sun 05 Apr 2026: Score -5
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | PEG Ratio | 2.1145 | 2.142 | ▲ 1.3% | Bearish. Lower is better. Slight increase, worsening the value relative to growth P/E ratio adjusted for growth rate |
| â | Forward PE | 22.7273 | 22.9885 | ▲ 1.15% | Bearish. Lower is better. Slight decline Stock price divided by expected future earnings |
| â | Price Sales TTM | 9.1657 | 9.2863 | ▲ 1.32% | Bearish. Lower is better. Higher multiple; market willing to pay more per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
| â | Price Book MRQ | 5.8939 | 5.9707 | ▲ 1.3% | Bearish. Lower is better. Further to 1; more overvalued on assets but worsened perception Stock price divided by book value per share for the most recent quarter |
| â | Enterprise Value/Revenue | 8.7855 | 8.9048 | ▲ 1.36% | Bearish. Lower is better. Slight decline Enterprise value divided by revenue |
| â | Enterprise Value/EBITDA | 21.6668 | 21.9612 | ▲ 1.36% | Bearish. Lower is better. Slight decline Enterprise value to earnings before interest, taxes, depreciation |
| â | Enterprise Value | $105.44B | $106.87B | ▲ 1.36% | Bullish. Higher is better. Increased, reflecting higher market cap and possibly debt adjustments Market capitalization plus debt minus cash |
Thu 12 Mar 2026 to Sun 29 Mar 2026: Score 13
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Forward PE | 25.8398 | 22.7273 | ▼ -12.05% | Bullish. Lower is better. Moderate improvement Stock price divided by expected future earnings |
| â | Price Sales TTM | 10.4209 | 9.1657 | ▼ -12.05% | Bullish. Lower is better. Lower multiple; market willing to pay less per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
| â | Price Book MRQ | 6.7011 | 5.8939 | ▼ -12.05% | Bullish. Lower is better. Closer to 1; less overvalued on assets but improved perception Stock price divided by book value per share for the most recent quarter |
| â | Enterprise Value/Revenue | 10.0409 | 8.7855 | ▼ -12.5% | Bullish. Lower is better. Moderate improvement Enterprise value divided by revenue |
| â | Enterprise Value/EBITDA | 24.7629 | 21.6668 | ▼ -12.5% | Bullish. Lower is better. Moderate improvement Enterprise value to earnings before interest, taxes, depreciation |
| â | Short Percent | 1.98% | 1.83% | ▼ -7.58% | Bullish. Lower is better. Slight decrease; still high, potential for squeeze if positive catalysts emerge Percentage of shares sold short |
| â | PEG Ratio | 2.1453 | 2.1145 | ▼ -1.44% | Bullish. Lower is better. Slight decrease, improving the value relative to growth P/E ratio adjusted for growth rate |
| â | Short Ratio | 2.78 | 2.9 | ▲ 4.32% | Bearish. Lower is better. Slight decline |
| â | Enterprise Value | $120.5B | $105.44B | ▼ -12.5% | Bearish. Higher is better. Decreased, reflecting lower market cap and possibly debt adjustments Market capitalization plus debt minus cash |
Thu 05 Mar 2026 to Thu 12 Mar 2026: Score -1
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Forward PE | 24.8139 | 25.8398 | ▲ 4.13% | Bearish. Lower is better. Slight decline Stock price divided by expected future earnings |
| â | Price Sales TTM | 10.1142 | 10.4209 | ▲ 3.03% | Bearish. Lower is better. Higher multiple; market willing to pay more per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
| â | Price Book MRQ | 6.4546 | 6.7011 | ▲ 3.82% | Bearish. Lower is better. Further to 1; more overvalued on assets but worsened perception Stock price divided by book value per share for the most recent quarter |
| â | Enterprise Value/Revenue | 9.6576 | 10.0409 | ▲ 3.97% | Bearish. Lower is better. Slight decline Enterprise value divided by revenue |
| â | Enterprise Value/EBITDA | 23.8175 | 24.7629 | ▲ 3.97% | Bearish. Lower is better. Slight decline Enterprise value to earnings before interest, taxes, depreciation |
| â | Wall Street Target Price | 535.5555 | 546.2593 | ▲ 2% | Bullish. Higher is better. Higher analyst expectations, pointing to increased optimism for future performance Analysts' consensus target price for the stock |
| â | Enterprise Value | $115.9B | $120.5B | ▲ 3.97% | Bullish. Higher is better. Increased, reflecting higher market cap and possibly debt adjustments Market capitalization plus debt minus cash |
| â | PEG Ratio | 2.4589 | 2.1453 | ▼ -12.75% | Bullish. Lower is better. Moderate decrease, improving the value relative to growth P/E ratio adjusted for growth rate |
Thu 26 Feb 2026 to Thu 05 Mar 2026: Score -10
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | PEG Ratio | 0.5801 | 2.4589 | ▲ 323.88% | Bearish. Lower is better. Extreme increase, worsening the value relative to growth P/E ratio adjusted for growth rate |
| â | Forward PE | 20.9205 | 24.8139 | ▲ 18.61% | Bearish. Lower is better. Moderate decline Stock price divided by expected future earnings |
| â | Enterprise Value/Revenue | 8.7549 | 9.6576 | ▲ 10.31% | Bearish. Lower is better. Moderate decline Enterprise value divided by revenue |
| â | Price Book MRQ | 6.1032 | 6.4546 | ▲ 5.76% | Bearish. Lower is better. Further to 1; more overvalued on assets but worsened perception Stock price divided by book value per share for the most recent quarter |
| â | Enterprise Value/EBITDA | 21.7761 | 23.8175 | ▲ 9.37% | Bearish. Lower is better. Slight decline Enterprise value to earnings before interest, taxes, depreciation |
| â | Price Sales TTM | 10.2235 | 10.1142 | ▼ -1.07% | Bullish. Lower is better. Lower multiple; market willing to pay less per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
| â | Short Ratio | 3.04 | 2.78 | ▼ -8.55% | Bullish. Lower is better. Slight improvement |
| â | Enterprise Value | $99.97B | $115.9B | ▲ 15.94% | Bullish. Higher is better. Increased, reflecting higher market cap and possibly debt adjustments Market capitalization plus debt minus cash |
Thu 19 Feb 2026 to Thu 26 Feb 2026: Score 7
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Forward PE | 25.1256 | 20.9205 | ▼ -16.74% | Bullish. Lower is better. Moderate improvement Stock price divided by expected future earnings |
| â | Enterprise Value/Revenue | 10.0049 | 8.7549 | ▼ -12.49% | Bullish. Lower is better. Moderate improvement Enterprise value divided by revenue |
| â | Enterprise Value/EBITDA | 25.7858 | 21.7761 | ▼ -15.55% | Bullish. Lower is better. Moderate improvement Enterprise value to earnings before interest, taxes, depreciation |
| â | Price Book MRQ | 6.6804 | 6.1032 | ▼ -8.64% | Bullish. Lower is better. Closer to 1; less overvalued on assets but improved perception Stock price divided by book value per share for the most recent quarter |
| â | Price Sales TTM | 9.9538 | 10.2235 | ▲ 2.71% | Bearish. Lower is better. Higher multiple; market willing to pay more per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
| â | Enterprise Value | $120.26B | $99.97B | ▼ -16.87% | Bearish. Higher is better. Decreased, reflecting lower market cap and possibly debt adjustments Market capitalization plus debt minus cash |
Thu 12 Feb 2026 to Thu 19 Feb 2026: Score 18
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Quarterly Earnings Growth YOY | 51% | 331% | ▲ 600% | Bullish. Higher is better. Quarterly earnings growth YOY growth accelerating. Year-over-year growth in quarterly earnings |
| â | Book Value | 68.197 | 73.49 | ▲ 7.76% | Bullish. Higher is better. Slight increase; stock now trades closer to book value Net asset value of the company per share |
| â | Earnings Per Share | 14.21 | 15.33 | ▲ 7.88% | Bullish. Higher is better. Slight increase in earnings per share Profit allocated to each outstanding share |
| â | EPS Estimate Current Year | 18.4327 | 19.1703 | ▲ 4% | Bullish. Higher is better. Slight increase; improved outlook for current year earnings Expected earnings per share this year |
| â | EPS Estimate Next Year | 20.1556 | 21.8854 | ▲ 8.58% | Bullish. Higher is better. Slight raised expectations for further out Expected earnings per share next year |
| â | Profit Margin | 31.35% | 32.94% | ▲ 5.07% | Bullish. Higher is better. Profit margin growth accelerating. Percentage of revenue that turns into profit |
| â | Gross Profit TTM | $6180.1M | $6440.5M | ▲ 4.21% | Bullish. Higher is better. Slight increase, but margins may be improving Revenue minus cost of goods sold over the trailing twelve months |
| â | Enterprise Value | $112.57B | $120.26B | ▲ 6.82% | Bullish. Higher is better. Increased, reflecting higher market cap and possibly debt adjustments Market capitalization plus debt minus cash |
| â | EBITDA | $4711.8M | $4866M | ▲ 3.27% | Bullish. Higher is better. Increase in earnings before interest, taxes, depreciation, and amortization; indicates stronger operational cash flow Earnings before interest, taxes, depreciation, and amortization |
| â | Wall Street Target Price | 514.32 | 530.0741 | ▲ 3.06% | Bullish. Higher is better. Higher analyst expectations, pointing to increased optimism for future performance Analysts' consensus target price for the stock |
| â | Return On Equity TTM | 22.31% | 22.54% | ▲ 1.03% | Bullish. Higher is better. Return on equity TTM growth accelerating. Efficiency in generating profits from shareholders' equity |
| â | Revenue TTM | $11723.3M | $12001.3M | ▲ 2.37% | Bullish. Higher is better. Slight top-line expansion Total revenue over the trailing twelve months |
| â | Revenue Per Share TTM | 45.683 | 46.935 | ▲ 2.74% | Bullish. Higher is better. Slight improvement Revenue generated per outstanding share over the trailing twelve months |
| â | Price Sales TTM | 10.0874 | 9.9538 | ▼ -1.32% | Bullish. Lower is better. Lower multiple; market willing to pay less per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
| â | Price Book MRQ | 6.7571 | 6.6804 | ▼ -1.14% | Bullish. Lower is better. Closer to 1; less overvalued on assets but improved perception Stock price divided by book value per share for the most recent quarter |
| â | Operating Margin TTM | 40.27% | 39.6% | ▼ -1.66% | Bearish. Higher is better. Operating margin TTM growth slowing. Percentage of revenue left after operating expenses |
| â | Forward PE | 23.5849 | 25.1256 | ▲ 6.53% | Bearish. Lower is better. Slight decline Stock price divided by expected future earnings |
| â | Enterprise Value/Revenue | 9.6025 | 10.0049 | ▲ 4.19% | Bearish. Lower is better. Slight decline Enterprise value divided by revenue |
| â | Enterprise Value/EBITDA | 24.1464 | 25.7858 | ▲ 6.79% | Bearish. Lower is better. Slight decline Enterprise value to earnings before interest, taxes, depreciation |
| â | Quarterly Revenue Growth YOY | 111% | 101% | ▼ -13.64% | Bearish. Higher is better. Quarterly revenue growth YOY growth slowing. Year-over-year growth in quarterly revenue |
Thu 05 Feb 2026 to Thu 12 Feb 2026: Score 2
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Short Ratio | 3.3 | 3.04 | ▼ -7.88% | Bullish. Lower is better. Slight improvement |
| â | Price Sales TTM | 10.2904 | 10.0874 | ▼ -1.97% | Bullish. Lower is better. Lower multiple; market willing to pay less per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
| â | Enterprise Value | $115.31B | $112.57B | ▼ -2.37% | Bearish. Higher is better. Decreased, reflecting lower market cap and possibly debt adjustments Market capitalization plus debt minus cash |
Thu 29 Jan 2026 to Thu 05 Feb 2026: Score 6
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Earnings Per Share | 14.19 | 14.35 | ▲ 1.13% | Bullish. Higher is better. Slight increase in earnings per share Profit allocated to each outstanding share |
| â | Forward PE | 24.2718 | 23.8095 | ▼ -1.9% | Bullish. Lower is better. Slight improvement Stock price divided by expected future earnings |
| â | Price Sales TTM | 10.452 | 10.2904 | ▼ -1.55% | Bullish. Lower is better. Lower multiple; market willing to pay less per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
| â | Price Book MRQ | 6.9465 | 6.8211 | ▼ -1.81% | Bullish. Lower is better. Closer to 1; less overvalued on assets but improved perception Stock price divided by book value per share for the most recent quarter |
| â | Enterprise Value/Revenue | 9.8823 | 9.6971 | ▼ -1.87% | Bullish. Lower is better. Slight improvement Enterprise value divided by revenue |
| â | Enterprise Value/EBITDA | 24.8501 | 24.3843 | ▼ -1.87% | Bullish. Lower is better. Slight improvement Enterprise value to earnings before interest, taxes, depreciation |
Thu 22 Jan 2026 to Thu 29 Jan 2026: Score 3
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Short Ratio | 3.84 | 3.3 | ▼ -14.06% | Bullish. Lower is better. Moderate improvement |
| â | Short Percent | 2.24% | 1.97% | ▼ -12.05% | Bullish. Lower is better. Moderate decrease; still high, potential for squeeze if positive catalysts emerge Percentage of shares sold short |
| â | Wall Street Target Price | 500.4 | 514.32 | ▲ 2.78% | Bullish. Higher is better. Higher analyst expectations, pointing to increased optimism for future performance Analysts' consensus target price for the stock |
| â | Enterprise Value | $112.55B | $115.85B | ▲ 2.94% | Bullish. Higher is better. Increased, reflecting higher market cap and possibly debt adjustments Market capitalization plus debt minus cash |
| â | Forward PE | 23.753 | 24.2718 | ▲ 2.18% | Bearish. Lower is better. Slight decline Stock price divided by expected future earnings |
| â | Price Sales TTM | 10.0852 | 10.452 | ▲ 3.64% | Bearish. Lower is better. Higher multiple; market willing to pay more per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
| â | Price Book MRQ | 6.7557 | 6.9465 | ▲ 2.82% | Bearish. Lower is better. Further to 1; more overvalued on assets but worsened perception Stock price divided by book value per share for the most recent quarter |
| â | Enterprise Value/Revenue | 9.6003 | 9.8823 | ▲ 2.94% | Bearish. Lower is better. Slight decline Enterprise value divided by revenue |
| â | Enterprise Value/EBITDA | 24.141 | 24.8501 | ▲ 2.94% | Bearish. Lower is better. Slight decline Enterprise value to earnings before interest, taxes, depreciation |
Wed 14 Jan 2026 to Thu 22 Jan 2026: Score -1
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Price Sales TTM | 9.9437 | 10.0852 | ▲ 1.42% | Bearish. Lower is better. Higher multiple; market willing to pay more per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
Tue 06 Jan 2026 to Wed 14 Jan 2026: Score -8
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Short Ratio | 3.08 | 3.84 | ▲ 24.68% | Bearish. Lower is better. Significant decline |
| â | Short Percent | 1.91% | 2.24% | ▲ 17.28% | Bearish. Lower is better. Moderate increase; still high, potential for squeeze if positive catalysts emerge Percentage of shares sold short |
| â | Price Sales TTM | 9.8153 | 9.9437 | ▲ 1.31% | Bearish. Lower is better. Higher multiple; market willing to pay more per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
| â | Price Book MRQ | 6.6237 | 6.7476 | ▲ 1.87% | Bearish. Lower is better. Further to 1; more overvalued on assets but worsened perception Stock price divided by book value per share for the most recent quarter |
| â | Enterprise Value/Revenue | 9.4053 | 9.5884 | ▲ 1.95% | Bearish. Lower is better. Slight decline Enterprise value divided by revenue |
| â | Enterprise Value/EBITDA | 23.6507 | 24.1111 | ▲ 1.95% | Bearish. Lower is better. Slight decline Enterprise value to earnings before interest, taxes, depreciation |
| â | Wall Street Target Price | 491.9167 | 500.4 | ▲ 1.72% | Bullish. Higher is better. Higher analyst expectations, pointing to increased optimism for future performance Analysts' consensus target price for the stock |
| â | Enterprise Value | $110.26B | $112.41B | ▲ 1.95% | Bullish. Higher is better. Increased, reflecting higher market cap and possibly debt adjustments Market capitalization plus debt minus cash |
Sun 21 Dec 2025 to Tue 06 Jan 2026: Score 2
| Metric | Previous | New | Change | Interpretation | |
|---|---|---|---|---|---|
| â | Price Sales TTM | 9.9772 | 9.8153 | ▼ -1.62% | Bullish. Lower is better. Lower multiple; market willing to pay less per dollar of sales Stock price divided by revenue per share over the trailing twelve months |
| â | Short Percent | 1.98% | 1.91% | ▼ -3.54% | Bullish. Lower is better. Slight decrease; still high, potential for squeeze if positive catalysts emerge Percentage of shares sold short |